CAS 134-03-2|sodium ascorbate
| Common Name | sodium ascorbate | ||
|---|---|---|---|
| CAS Number | 134-03-2 | Molecular Weight | 198.106 |
| Density | 1.799 g/cm3 | Boiling Point | 552.7ºC at 760 mmHg |
| Molecular Formula | C6H7NaO6 | Melting Point | 220 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 238.2ºC |
Names
| Name | Sodium L-Ascorbate |
|---|---|
| Synonym | More Synonyms |
sodium ascorbate BiologicalActivity
| Description | L-Ascorbic acid (sodium) is a more bioavailable form of vitamin C that is an antioxidant agent. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerNatural Products >>Others |
| In Vitro | Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis[1]. The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by sodium L-ascorbate (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[2]. |
| In Vivo | Tg rats treated with sodium L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium L-ascorbate (15.4%). Independent of the sodium L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[3]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[4]. |
| Animal Admin | A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively. |
| References | [1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [2]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [3]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [4]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. |
Chemical & Physical Properties
| Density | 1.799 g/cm3 |
|---|---|
| Boiling Point | 552.7ºC at 760 mmHg |
| Melting Point | 220 °C (dec.)(lit.) |
| Molecular Formula | C6H7NaO6 |
| Molecular Weight | 198.106 |
| Flash Point | 238.2ºC |
| Exact Mass | 198.014038 |
| PSA | 110.05000 |
| Vapour Pressure | 1.62E-14mmHg at 25°C |
| Index of Refraction | 105.5 ° (C=10, H2O) |
| InChIKey | PPASLZSBLFJQEF-RXSVEWSESA-M |
| SMILES | O=C1OC(C(O)CO)C([O-])=C1O.[Na+] |
| Water Solubility | 620 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 500 umol/L
- REFERENCE :
- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,299,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0461 No. of Facilities: 474 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 16211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0461 No. of Facilities: 705 (estimated) No. of Industries: 11 No. of Occupations: 28 No. of Employees: 24087 (estimated) No. of Female Employees: 15231 (estimated)
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 500 umol/L
- REFERENCE :
- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,299,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0461 No. of Facilities: 474 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 16211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0461 No. of Facilities: 705 (estimated) No. of Industries: 11 No. of Occupations: 28 No. of Employees: 24087 (estimated) No. of Female Employees: 15231 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Risk Phrases | R68 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | CI7671000 |
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Synonyms
| EINECS 205-126-1 |
| Sodium ascorbate |
| L-Ascorbic Acid Sodium Salt |
| Vitamine C sodium salt,Vitamin C sodium salt |
| (+)-Sodium L-ascorbate (L(+)-Ascorbic acid sodium salt |
| SodiuM L-Ascorbate |
| L(+)-Ascorbic acid sodium salt,Vitamin C sodium salt |
| MFCD00082340 |
| Vitamin C Sodium Salt |
| L(+)-Ascorbic acid sodium salt,E301 |
