CAS 36141-82-9|Diamfenetide

Introduction：Basic information about CAS 36141-82-9|Diamfenetide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Diamfenetide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Diamfenetide
CAS Number	36141-82-9	Molecular Weight	372.41500
Density	1.225g/cm3	Boiling Point	661.8ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅	Melting Point	/
MSDS	/	Flash Point	354.1ºC

Names

Name	N-[4-[2-[2-(4-acetamidophenoxy)ethoxy]ethoxy]phenyl]acetamide
Synonym	More Synonyms

Diamfenetide BiologicalActivity

Description	Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica[1].
Related Catalog	Research Areas >>Infection
In Vitro	Diamfenetide (10-100 μM; 1-3 hours) treatment leads a time/dose-dependent, irreversible paralysis that involves an increase in muscular tension and decrease in contraction amplitude in vitro of immature and adult Fasciola hepatica[1]. Diamfenetide (100 μM; 6-24 hours) increases products of glucose metabolism by adult Fasciola hepatica in vitro. And the metabolic effects of Diamfenetide on F. hepatica may be secondary to the initial effects on surface membranes[2].
References	[1]. R S Rew, et al. Fasciola Hepatica: Effects of Diamfenetide Free Amine on in Vitro Physiology, Biochemistry, and Morphology. Exp Parasitol [2]. R S Rew, et al. Effects of Diamfenetide on Metabolic and Excretory Functions of Fasciola Hepatica in Vitro. Comp Biochem Physiol C

Chemical & Physical Properties

Density	1.225g/cm3
Boiling Point	661.8ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅
Molecular Weight	372.41500
Flash Point	354.1ºC
Exact Mass	372.16900
PSA	85.89000
LogP	3.22380
Index of Refraction	1.595
InChIKey	JNEZCZPNQCQCFK-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccc(OCCOCCOc2ccc(NC(C)=O)cc2)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7042000

CHEMICAL NAME :: Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-

CAS REGISTRY NUMBER :: 36141-82-9

BEILSTEIN REFERENCE NO. :: 2179741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2-O5

MOLECULAR WEIGHT :: 372.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 22(4),59,1988

Safety Information

HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Diamfenetide

bis-[2-(4-acetylamino-phenoxy)-ethyl]-ether

diamphenethide

Coryphamin

Bis-[2-(4-acetylamino-phenoxy)-aethyl]-aether

N,N'-<Oxybis<2,1-(ethanediyloxy)-4,1-phenylene>>bisacetamide

Acemidophene

EINECS 252-886-5

Compound 68-198

Diamfenetidum [INN-Latin]

Diamfenetida [INN-Spanish]

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