Introduction：Basic information about CAS 61220-69-7|Tiopinac, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiopinac |
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| CAS Number | 61220-69-7 | Molecular Weight | 284.33000 |
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| Density | 1.372g/cm3 | Boiling Point | 541.3ºC at 760 mmHg |
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| Molecular Formula | C16H12O3S | Melting Point | / |
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| MSDS | / | Flash Point | 281.1ºC |
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Names
| Name | 2-(11-oxo-6H-benzo[c][1]benzothiepin-3-yl)acetic acid |
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| Synonym | More Synonyms |
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Tiopinac BiologicalActivity
| Description | Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vivo | Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1]. |
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| Animal Admin | Female rats, 160-180 g, receive 0.1 mL of a suspension in mineral oil of heatkilled M. butyricum (10 mg/mL) by means of two intradermal injections (0.05 mL each) into the proximal 1/4 of the tail on day 0. When the test agent is studied for its activity versus the development of the arthritic syndrome, it is administered p.o. (0.5 mL vehicle/dose) twice each day (at 9 a.m. and 4 p.m.) for 17 days, beginning on day 1. On day 18 the intensity of the swelling of the four foot pads and tail is determined blindly utilizing a scoring system in which the swelling in the four paws is scored 0-4 for each paw and the tail swelling is scored 0-3. The total maximum score is 19. The body weights and the weights of both hind paws are obtained. This procedure is a modification of a system initially described by PEARSON. |
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| References | [1]. Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73. |
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Chemical & Physical Properties
| Density | 1.372g/cm3 |
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| Boiling Point | 541.3ºC at 760 mmHg |
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| Molecular Formula | C16H12O3S |
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| Molecular Weight | 284.33000 |
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| Flash Point | 281.1ºC |
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| Exact Mass | 284.05100 |
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| PSA | 79.67000 |
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| LogP | 3.15040 |
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| Index of Refraction | 1.674 |
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| InChIKey | KLIVRBFRQSOGQI-UHFFFAOYSA-N |
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| SMILES | O=C(O)Cc1ccc2c(c1)SCc1ccccc1C2=O |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| UNII-1QX5LNW7CG |
| Tiopinacum |
| (11-oxo-6,11-dihydrodibenz[b,e]thiepin-3-yl)acetic acid |
| Tiopinacum [INN-Latin] |
| Tiopinac (USAN/INN) |
| Tiopinaco [INN-Spanish] |
| Tiopinaco |
| 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid |
| TIOPINAC |
