Introduction：Basic information about CAS 25387-67-1|20(S)-Camptothecin sodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 20(S)-Camptothecin sodium salt |
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| CAS Number | 25387-67-1 | Molecular Weight | 388.34900 |
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| Density | / | Boiling Point | 777.3ºC at 760 mmHg |
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| Molecular Formula | C20H17N2NaO5 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 423.9ºC |
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Names
| Name | sodium camptothecin |
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| Synonym | More Synonyms |
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20(S)-Camptothecin sodium salt BiologicalActivity
| Description | Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and, intracellularly, causes breaks in preformed viral DNA[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| In Vitro | Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis[1]. Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA [1]. |
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| References | [1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14. [2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8 |
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Chemical & Physical Properties
| Boiling Point | 777.3ºC at 760 mmHg |
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| Molecular Formula | C20H17N2NaO5 |
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| Molecular Weight | 388.34900 |
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| Flash Point | 423.9ºC |
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| Exact Mass | 388.10400 |
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| PSA | 115.48000 |
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| LogP | 0.26500 |
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| Vapour Pressure | 1.96E-25mmHg at 25°C |
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| InChIKey | PBJLMBQVBUDNJL-BDQAORGHSA-N |
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| SMILES | CCC(O)(C(=O)O)c1cc2n(c(=O)c1CO)Cc1cc3ccccc3nc1-2.[Na] |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EX1650000
- CHEMICAL NAME :
- Camptothecin, sodium salt
- CAS REGISTRY NUMBER :
- 25387-67-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H18-N2-O5.Na
- MOLECULAR WEIGHT :
- 389.39
- WISWESSER LINE NOTATION :
- T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 2500 ug/kg/7D-I
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified)
- REFERENCE :
- CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 151 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 57 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
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Safety Information
| Hazard Codes | T+ |
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| HS Code | 2942000000 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| camptothecinsodium |
| camptothecin,sodiumsalt |
| 21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt |
| Fda 1660 |
| 21,22-secocamptothecin-21-oicacid,monosodiumsalt |
| 20(s)-camptothecinsodiumsalt |
| camptothecin Na |
| camptothecinesodium |
| CaMphotecin sodiuM |
