Introduction：Basic information about CAS 131926-98-2|5-Hydroxylansoprazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Hydroxylansoprazole |
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| CAS Number | 131926-98-2 | Molecular Weight | 385.36100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C16H14F3N3O3S | Melting Point | >155ºC (dec.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-hydroxy lansoprazole |
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| Synonym | More Synonyms |
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5-Hydroxylansoprazole BiologicalActivity
| Description | 5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Proton Pump |
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| Target | Proton Pump[1] |
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| References | [1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220. [2]. Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963(2019). |
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Chemical & Physical Properties
| Melting Point | >155ºC (dec.) |
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| Molecular Formula | C16H14F3N3O3S |
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| Molecular Weight | 385.36100 |
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| Exact Mass | 385.07100 |
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| PSA | 107.31000 |
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| LogP | 4.08650 |
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| InChIKey | IDCLTMRSSAXUNY-UHFFFAOYSA-N |
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| SMILES | Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccc(O)cc2[nH]1 |
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Synonyms
| 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazol-5-ol |
| 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylsulfinyl]-5-hydroxy-1H-benzimidazole |
| AG-1908 |
| 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole-5-ol |
| 5'-hydroxylansoprazole |
| Lansoprazole Impurity 18 |
