CAS 1612-76-6|5-Phenyl-1,3,4-oxadiazol-2-amine

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RO0620000

CHEMICAL NAME :

1,3,4-Oxadiazole, 2-amino-5-phenyl-

CAS REGISTRY NUMBER :

1612-76-6

LAST UPDATED :

199009

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C8-H7-N3-O

MOLECULAR WEIGHT :

161.18

WISWESSER LINE NOTATION :

T5NN DOJ CZ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 9,478,1966

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

219 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

REFERENCE :

FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,629,1958