Introduction：Basic information about CAS 13268-67-2|Senecionine N-oxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Senecionine N-oxide |
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| CAS Number | 13268-67-2 | Molecular Weight | 351.39400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H25NO6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Senecionine, N-oxide |
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| Synonym | More Synonyms |
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Senecionine N-oxide BiologicalActivity
| Description | Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643 [2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3. |
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Chemical & Physical Properties
| Molecular Formula | C18H25NO6 |
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| Molecular Weight | 351.39400 |
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| Exact Mass | 351.16800 |
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| PSA | 102.26000 |
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| LogP | 1.16420 |
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| InChIKey | PLGBHVNNYDZWGZ-GPUZEBNTSA-N |
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| SMILES | CC=C1CC(C)C(C)(O)C(=O)OCC2=CC[N+]3([O-])CCC(OC1=O)C23 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VT5720000
- CHEMICAL NAME :
- Senecionan-11,16-dione, 12-hydroxy-, 4-oxide
- CAS REGISTRY NUMBER :
- 13268-67-2
- LAST UPDATED :
- 198912
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C18-H25-N-O5
- MOLECULAR WEIGHT :
- 335.44
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 140 mg/kg
- SEX/DURATION :
- female 4-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 77,461,1988
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | UN 1544 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| 12-Hydroxysenecionan-11,16-dione 4-oxide |
| Senecionine oxide |
| integerrimine N-oxide |
| senecionine N-oxide |
