Introduction：Basic information about CAS 39026-92-1|9-Methoxycamptothecine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 9-Methoxycamptothecine |
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| CAS Number | 39026-92-1 | Molecular Weight | 378.378 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 773.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C21H18N2O5 | Melting Point | 223-225 ºC |
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| MSDS | / | Flash Point | 421.4±32.9 °C |
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Names
| Name | 9-Methoxycamptothecin |
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| Synonym | More Synonyms |
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9-Methoxycamptothecine BiologicalActivity
| Description | 9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase |
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| Target | Topoisomerase[1]. Apoptosis[2]. |
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| References | [1]. Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66(9-10):471-6. [2]. Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 773.1±60.0 °C at 760 mmHg |
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| Melting Point | 223-225 ºC |
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| Molecular Formula | C21H18N2O5 |
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| Molecular Weight | 378.378 |
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| Flash Point | 421.4±32.9 °C |
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| Exact Mass | 378.121582 |
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| PSA | 90.65000 |
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| LogP | 2.00 |
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| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
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| Index of Refraction | 1.723 |
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| InChIKey | XVMZDZFTCKLZTF-NRFANRHFSA-N |
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| SMILES | CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(OC)cccc3nc2-1 |
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| Storage condition | 2-8°C |
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| Water Solubility | Slightly soluble (2.7 g/L) (25 ºC) |
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Synonyms
| 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)- |
| 10-methoxycamptothecin |
| 9-methoxycamtothecin |
| (4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Camptothecin,9-methoxy |
