Introduction：Basic information about CAS 138-92-1|Betazole dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Betazole dihydrochloride |
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| CAS Number | 138-92-1 | Molecular Weight | 184.06700 |
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| Density | / | Boiling Point | 284.1ºC at 760mmHg |
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| Molecular Formula | C5H11Cl2N3 | Melting Point | 224-226° |
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| MSDS | / | Flash Point | 150.3ºC |
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Names
| Name | betazole dihydrochloride |
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| Synonym | More Synonyms |
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Betazole dihydrochloride BiologicalActivity
| Description | Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H2 Receptor |
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| In Vitro | Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion[1]. |
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| References | [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. |
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Chemical & Physical Properties
| Boiling Point | 284.1ºC at 760mmHg |
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| Melting Point | 224-226° |
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| Molecular Formula | C5H11Cl2N3 |
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| Molecular Weight | 184.06700 |
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| Flash Point | 150.3ºC |
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| Exact Mass | 183.03300 |
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| PSA | 54.70000 |
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| LogP | 2.21520 |
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| Vapour Pressure | 0.00303mmHg at 25°C |
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| InChIKey | BUXCUOWXTOKEMQ-UHFFFAOYSA-N |
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| SMILES | Cl.Cl.NCCc1ccn[nH]1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UQ5600000
- CHEMICAL NAME :
- Pyrazole, 3-(2-aminoethyl)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 138-92-1
- LAST UPDATED :
- 199404
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H9-N3.2Cl-H
- MOLECULAR WEIGHT :
- 184.09
- WISWESSER LINE NOTATION :
- T5MNJ C2Z &GH 2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Ocular
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 740 ug/kg/37D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human)
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,275,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Ocular
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 86 ug/kg/6D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,274,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 803 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83995 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)
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Safety Information
| Hazard Codes | Xn |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933199090 |
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Customs
| HS Code | 2933199090 |
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| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1h-pyrazole-3-ethanamine,dihydrochloride |
| BETAZOLE HYDROCHLORIDE (200 MG) |
| 3-(2-aminoethyl)-pyrazoldihydrochloride |
| histalog |
| [2-(1H-Pyrazol-3-yl)ethyl]amine dihydrochloride |
| ametazoledihydrochloride |
| Betazole hydrochloride |
| 2-(1(2)H-pyrazol-3-yl)-ethylamine,dihydrochloride |
| gastramine |
| 2-(1(2)H-Pyrazol-3-yl)-aethylamin,Dihydrochlorid |
| 3-(2-aminoethyl)pyrazole,dihydrochloride |
| Histimin |
