CAS 130348-88-8|(2H24)Tetradecanedioic acid

Introduction：Basic information about CAS 130348-88-8|(2H24)Tetradecanedioic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(2H24)Tetradecanedioic acid
CAS Number130348-88-8Molecular Weight282.502
Density1.0±0.1 g/cm3Boiling Point434.1±18.0 °C at 760 mmHg
Molecular FormulaC14H2D24O4Melting Point/
MSDS/Flash Point230.5±17.7 °C

Names

Name1,14-tetradecanedioic-d24 acid
SynonymMore Synonyms

(2H24)Tetradecanedioic acid BiologicalActivity

DescriptionTetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated drug-drug interactions[2].
Related CatalogResearch Areas >>Metabolic Disease
In VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Santockyte R, et al. LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions. Bioanalysis. 2018 Sep 1;10(18):1473-1485.  

Chemical & Physical Properties

Density1.0±0.1 g/cm3
Boiling Point434.1±18.0 °C at 760 mmHg
Molecular FormulaC14H2D24O4
Molecular Weight282.502
Flash Point230.5±17.7 °C
Exact Mass282.333740
PSA74.60000
LogP3.99
Vapour Pressure0.0±2.2 mmHg at 25°C
Index of Refraction1.475

Synonyms

Tetradecanedioic-d acid
(H)Tetradecanedioic acid
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