Introduction：Basic information about CAS 61545-06-0|Temocillin disodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Temocillin disodium salt |
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| CAS Number | 61545-06-0 | Molecular Weight | 458.42 |
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| Density | 1.6g/cm3 | Boiling Point | 761.9ºC at 760mmHg |
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| Molecular Formula | C16H16N2Na2O7S2 | Melting Point | / |
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| MSDS | / | Flash Point | 414.6ºC |
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Names
| Name | temocillin disodium |
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| Synonym | More Synonyms |
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Temocillin disodium salt BiologicalActivity
| Description | Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity[1]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Temocillin dosing regimens of 200 mg/kg every 4 and 6 h remained significantly effective in reducing bacterial titres in kidneys against the two strains, with no significant difference between the parental strain and its transconjugant[2]. |
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| References | [1]. K Jules, et al. Antibacterial activity and beta-lactamase stability of temocillin. Antimicrob Agents Chemother. 1982 Sep;22(3):453-60. [2]. J F Soubirou, et al. Activity of temocillin in a murine model of urinary tract infection due to Escherichia coli producing or not producing the ESBL CTX-M-15. J Antimicrob Chemother. 2015 May;70(5):1466-72. |
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Chemical & Physical Properties
| Density | 1.6g/cm3 |
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| Boiling Point | 761.9ºC at 760mmHg |
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| Molecular Formula | C16H16N2Na2O7S2 |
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| Molecular Weight | 458.42 |
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| Flash Point | 414.6ºC |
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| Exact Mass | 414.05600 |
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| PSA | 190.27000 |
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| LogP | 1.30030 |
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| InChIKey | MRGCZDWBFFUEES-CWBCWDDISA-L |
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| SMILES | COC1(NC(=O)C(C(=O)[O-])c2ccsc2)C(=O)N2C(C(=O)[O-])C(C)(C)SC21.[Na+].[Na+] |
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Synonyms
| 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,6-((carboxy-3-thienylacetyl)amino)-6-methoxy-3,3-dimethyl-7-oxo-,disodium salt,(2S,5R,6S) |
| disodium,(2S,5R,6S)-6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| UNII-96IIP39ODH |
| Negaban (TN) |
| Temocillin disodium salt |
| EINECS 262-835-9 |
| Temocillin sodium |
| Temocillin |
