CAS 1354-84-3|Bullatine A

Introduction：Basic information about CAS 1354-84-3|Bullatine A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bullatine A BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Bullatine A
CAS Number	1354-84-3	Molecular Weight	343.503
Density	1.2±0.1 g/cm3	Boiling Point	488.2±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₃NO₂	Melting Point	/
MSDS	/	Flash Point	242.3±27.4 °C

Names

Name	Bullatine A
Synonym	More Synonyms

Bullatine A BiologicalActivity

Description	Bullatine A (BLA), a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A (BLA) is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1].Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].
Related Catalog	Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor
References	[1]. Li J, et al. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Res Bull. 2013 Aug;97:81-5. [2]. Huang Q, et al. Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models. J Neuroinflammation. 2016 Aug 30;13(1):214.

Description

Bullatine A (BLA), a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A (BLA) is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1].Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].

Related Catalog

Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor

References

[1]. Li J, et al. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Res Bull. 2013 Aug;97:81-5.

[2]. Huang Q, et al. Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models. J Neuroinflammation. 2016 Aug 30;13(1):214.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	488.2±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₃NO₂
Molecular Weight	343.503
Flash Point	242.3±27.4 °C
Exact Mass	343.251129
PSA	43.70000
LogP	3.07
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.620
InChIKey	OVXLNQAYPUEDSI-UHFFFAOYSA-N
SMILES	C=C1C2CCC3(C1O)C1CC4C5(C)CCCC4(C1N(CC)C5)C3C2O

Safety Information

HS Code	29339900

Synonyms

21-Ethyl-4-methyl-7,20-cycloatid-16-ene-11,15-diol

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