Introduction：Basic information about CAS 25422-31-5|Fibrinopeptide A human, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fibrinopeptide A human |
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| CAS Number | 25422-31-5 | Molecular Weight | 1536.56000 |
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| Density | 1.53 g/cm3 | Boiling Point | / |
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| Molecular Formula | C63H97N19O26 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | Fibrinopeptide A |
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| Synonym | More Synonyms |
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Fibrinopeptide A human BiologicalActivity
| Description | Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular DiseasePeptides |
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| In Vitro | The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to the central region of fibrinogen and catalyzes cleavage of the 2 short peptides, the 16-residue fibrinopeptide A (FpA) and the 14-residue fibrinopeptide B (FpB), located at the NH2-termini of the Aα and Bβ chains, respectively[1]. |
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| In Vivo | Fibrinopeptide A (FPA) is a small polypeptide cleaved from fibrinogen by thrombin, has a short half-life, and is considered a sensitive biochemical marker of thrombin activity, fibrin generation, and ongoing thrombosis[2]. |
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| References | [1]. Riedel T, et al. Fibrinopeptides A and B release in the process of surface fibrin formation. Blood. 2011 Feb 3;117(5):1700-6. [2]. Manolis AS, et al. Plasma level changes of fibrinopeptide A after uncomplicated coronary angioplasty. Clin Cardiol. 1993 Jul;16(7):548-52. |
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Chemical & Physical Properties
| Density | 1.53 g/cm3 |
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| Molecular Formula | C63H97N19O26 |
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| Molecular Weight | 1536.56000 |
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| Exact Mass | 1535.69000 |
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| PSA | 731.15000 |
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| InChIKey | JWICNZAGYSIBAR-UHFFFAOYSA-N |
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| SMILES | CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CCCN=C(N)N)C(=O)O)C(C)C |
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| Storage condition | −20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Articles33
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| Thromboprophylaxis in patients receiving chemotherapy. N. Engl. J. Med. 366(19) , 1839; author reply 1839-40, (2012)
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| Routine heparin for patients with cancer? One answer, more questions. N. Engl. J. Med. 366(7) , 661-2, (2012)
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| Congenital dysfibrinogenemia Aα Gly13Glu associated with bleeding during pregnancy. Thromb. Res. 127(3) , 277-8, (2011)
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Synonyms
| fibrinopeptide a, human |
| MFCD00076437 |
| ADSGEGDFLAEGGGVR |
