Introduction：Basic information about CAS 131707-25-0|Arbidol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Arbidol |
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| CAS Number | 131707-25-0 | Molecular Weight | 477.41 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 591.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H25BrN2O3S | Melting Point | / |
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| MSDS | / | Flash Point | 311.7±30.1 °C |
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Names
| Name | ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate |
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| Synonym | More Synonyms |
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Arbidol BiologicalActivity
| Description | Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoV |
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| In Vitro | Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV[1]. |
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| In Vivo | Umifenovir (25 and 45 mg/ml; p.o.;) shows a survival benefit to mice suffering from influenza infection[3]. Animal Model: BALB/c mice (6–8 weeks old), mice were intranasally (i.n.) inoculated with 2 times the 50% mouse lethal dose (MLD50) of A/ Guangdong/GIRD07/09 (H1N1) (104.5TCID50/mL) in a volume of 20mL[3]. Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi) Administration: Oral administration Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group. |
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| References | [1]. Julie Blaising, et al. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94. doi: 10.1016/j.antiviral.2014.04.006. Epub 2014 Apr 24. [2]. Irina Leneva, et al. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021 Aug 23;13(8):1665. [3]. Yutao Wang, et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed Pharmacother. 2017 Jul;91:393-401. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 591.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H25BrN2O3S |
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| Molecular Weight | 477.41 |
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| Flash Point | 311.7±30.1 °C |
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| Exact Mass | 476.076904 |
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| PSA | 80.00000 |
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| LogP | 4.64 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.620 |
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| InChIKey | KCFYEAOKVJSACF-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 |
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Synonyms
| 1H-Indole-3-carboxylic acid, 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester |
| 1-methyl-2-phenylthiomethyl-3-ethoxycarbonyl-4-dimethylaminomethyl-5-hydroxy-6-bromindole |
| ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylate |
| Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate |
| Umifenovir |
| 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester |
| 6-bromo-4-dimethylaminomethyl-3-ethoxycarbonyl-5-hydroxy-1-methyl-2-phenylthiomethylindole |
| Arbidol |
| 1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimethylaminomethyl-5-oxy-6-bromoindole |
| HMS589B06 |
