CAS 1393-48-2|Thiostrepton

Introduction：Basic information about CAS 1393-48-2|Thiostrepton, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Thiostrepton BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles32
7. Synonyms

Common Name	Thiostrepton
CAS Number	1393-48-2	Molecular Weight	1664.89000
Density	1.64 g/cm3	Boiling Point	/
Molecular Formula	C₇₂H₈₅N₁₉O₁₈S₅	Melting Point	248-257°C (dec.)
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	thiostrepton
Synonym	More Synonyms

Thiostrepton BiologicalActivity

Description	Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>InfectionNatural Products >>OthersPeptides

Chemical & Physical Properties

Density	1.64 g/cm3
Melting Point	248-257°C (dec.)
Molecular Formula	C₇₂H₈₅N₁₉O₁₈S₅
Molecular Weight	1664.89000
Exact Mass	1663.49000
PSA	701.00000
LogP	4.08640
Index of Refraction	1.768
InChIKey	NSFFHOGKXHRQEW-AIHSUZKVSA-N
SMILES	C=C(NC(=O)C(=C)NC(=O)c1csc(C2=NC3c4csc(n4)C4NC(=O)c5csc(n5)C(C(C)(O)C(C)O)NC(=O)C5CSC(=N5)C(=CC)NC(=O)C(C(C)O)NC(=O)c5csc(n5)C3(CC2)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC(=O)C(C(C)CC)NC2C=Cc3c(C(C)O)cc(nc3C2O)C(=O)OC4C)n1)C(N)=O
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN6300100

CHEMICAL NAME :: Thiostrepton

CAS REGISTRY NUMBER :: 1393-48-2

LAST UPDATED :: 199506

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C72-H85-N19-O18-S5

MOLECULAR WEIGHT :: 1665.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,63,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),396,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),396,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),397,1980

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XN6300100

Articles32

ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro.

Plant Mol. Biol. 78(1-2) , 185-96, (2012)

Chloroplasts possess common biosynthetic pathways for generating guanosine 3',5'-(bis)pyrophosphate (ppGpp) from GDP and ATP by RelA-SpoT homolog enzymes. To date, several hypothetical targets of ppGp...

Development of a vector and host system and characterization of replication of plasmid pSQ10 in moderately halophilic Nocardiopsis.

Acta Biochim. Biophys. Sin. (Shanghai) 43(9) , 738-43, (2011)

The genus of Nocardiopsis is a new source of antibiotics, chemicals, and enzymes. Here we reported the development of a vector and host system in moderately halophilic Nocardiopsis via an oriT-mediate...

Thiostrepton, proteasome inhibitors and FOXM1.

Cell Cycle 10(24) , 4341-2, (2011)

Synonyms

MFCD00135828

Thiostrepton

EINECS 215-734-9

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