CAS 134523-01-6|Atorvastatin Sodium

Introduction：Basic information about CAS 134523-01-6|Atorvastatin Sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Atorvastatin Sodium BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Atorvastatin Sodium
CAS Number	134523-01-6	Molecular Weight	580.62
Density	1.2±0.1 g/cm3	Boiling Point	722.2±60.0ºC at 760 mmHg
Molecular Formula	C₃₃H₃₄FN₂NaO₅	Melting Point	/
MSDS	/	Flash Point	390.6±32.9ºC

Names

Name	atorvastatin sodium
Synonym	More Synonyms

Atorvastatin Sodium BiologicalActivity

Description	Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease
References	[1]. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Description

Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease

References

[1]. Br J Pharmacol. 2006 Sep;149(1):14-22.

[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

[3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.

[4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.

[5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.

[6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	722.2±60.0ºC at 760 mmHg
Molecular Formula	C₃₃H₃₄FN₂NaO₅
Molecular Weight	580.62
Flash Point	390.6±32.9ºC
Exact Mass	580.234924
PSA	114.62000
LogP	5.05190
InChIKey	VVRPOCPLIUDBSA-CNZCJKERSA-M
SMILES	CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC(O)CC(O)CC(=O)[O-].[Na+]

Synonyms

1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, sodium salt, (βR,δR)- (1:1)

Atorvastatin Sodium

Sodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate

atorvastatin sodium salt

3R,5R-Atorvastaatin Sodium salt

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