CAS 6153-33-9|Mebhydrolin napadisylate
Introduction：Basic information about CAS 6153-33-9|Mebhydrolin napadisylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mebhydrolin napadisylate | ||
|---|---|---|---|
| CAS Number | 6153-33-9 | Molecular Weight | 841.048 |
| Density | 0.9799 (rough estimate) | Boiling Point | 457.3ºC at 760 mmHg |
| Molecular Formula | C48H48N4O6S2 | Melting Point | 280°C (rough estimate) |
| MSDS | USA | Flash Point | 230.4ºC |
Names
| Name | Mebhydrolin Napadisylate |
|---|---|
| Synonym | More Synonyms |
Mebhydrolin napadisylate BiologicalActivity
| Description | Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/Immunology |
| Target | Histamine H1-receptor[1] |
| In Vitro | Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2]. |
| References | [1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9. |
Chemical & Physical Properties
| Density | 0.9799 (rough estimate) |
|---|---|
| Boiling Point | 457.3ºC at 760 mmHg |
| Melting Point | 280°C (rough estimate) |
| Molecular Formula | C48H48N4O6S2 |
| Molecular Weight | 841.048 |
| Flash Point | 230.4ºC |
| Exact Mass | 840.301514 |
| PSA | 141.84000 |
| LogP | 10.72560 |
| Index of Refraction | 1.8676 (estimate) |
| InChIKey | CJUOSBUQOWKEKJ-UHFFFAOYSA-N |
| SMILES | CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1.CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1.O=S(=O)(O)c1cccc2c(S(=O)(=O)O)cccc12 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,539,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| RTECS | QJ6845000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles13
More Articles| Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril). Int. J. Clin. Pharmacol. Ther. 33 , 373, (1995) The efficacy of a multiple oral dose treatment with mebhydroline (Omeril coated tablets, 100 mg t.i.d.) was examined in 3 studies which were performed in a randomized, double-blind and placebo-control... | |
| Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 135(1) , 111-21, (2008) This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C v... | |
| [Agranulocytosis associated with mebhydrolin napadisylate (Incidal)]. Harefuah 106(5) , 208-9, (1984) |
Synonyms
| Mebhydroline 1,5-naphthalenedisulfonate salt |
| diazoline |
| Naphthalene-1,5-disulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2) |
| 1,5-Naphthalenedisulfonic acid - 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (1:2) |
| 1,5-Naphthalenedisulfonic acid, compd. with 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole (1:2) |
| Mebhydrolin napadisylate |
| Mebhydroline Napadisylate |
