Introduction：Basic information about CAS 25523-97-1|Dexchlorpheniramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dexchlorpheniramine |
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| CAS Number | 25523-97-1 | Molecular Weight | 274.78800 |
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| Density | 1.107g/cm3 | Boiling Point | 379ºC at 760mmHg |
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| Molecular Formula | C16H19ClN2 | Melting Point | / |
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| MSDS | / | Flash Point | 183ºC |
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Names
| Name | dexchlorpheniramine |
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| Synonym | More Synonyms |
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Dexchlorpheniramine BiologicalActivity
| Description | Dexchlorpheniramine is an potent and blood-brain barrier (BBB) penetrant histamine 1 (H1) receptor antagonist with anticholinergic properties. Dexchlorpheniramine can be used for researching allergies[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| In Vivo | Dexchlorpheniramine (2-10 mg/kg; IP, single dosage) and Ranitidine (10-50 mg/kg) co-administration can Simultaneous blockade of H1 and H2 receptors, and protects both the cortical plate and the white matter against the excitotoxic challenge in Swiss pups pretreated with IL-9[1]. |
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| References | [1]. Patkai J, et al. Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res. 2001 Aug;50(2):222-30. |
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Chemical & Physical Properties
| Density | 1.107g/cm3 |
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| Boiling Point | 379ºC at 760mmHg |
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| Molecular Formula | C16H19ClN2 |
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| Molecular Weight | 274.78800 |
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| Flash Point | 183ºC |
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| Exact Mass | 274.12400 |
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| PSA | 16.13000 |
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| LogP | 3.81860 |
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| Index of Refraction | 1.565 |
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| InChIKey | SOYKEARSMXGVTM-HNNXBMFYSA-N |
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| SMILES | CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1 |
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Synonyms
| Phendextro |
| (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine |
| D-Chlorpheniramine |
| dexchlorphenamine |
| Isomerine |
| Dexclorfeniramina |
| Fortamine |
| Trenelone |
| Polaramin |
| DEXCHLORPHENIRAMINE |
| Destral |
