Introduction：Basic information about CAS 443302-08-7|ZnAF-1F, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ZnAF-1F |
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| CAS Number | 443302-08-7 | Molecular Weight | 608.59100 |
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| Density | 1.49g/cm3 | Boiling Point | 822.1ºC at 760 mmHg |
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| Molecular Formula | C34H26F2N4O5 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 451ºC |
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Names
| Name | 5-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-2-(2,7-difluoro-3-hydroxy-6-oxoxanthen-9-yl)benzoic acid |
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| Synonym | More Synonyms |
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ZnAF-1F BiologicalActivity
| Description | ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm[1][2][3]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | ZnAF-1F (1 µM) shows an Kon value of 3.5*106 M-1s-1, and an Koff value of 7.7*10-3 s-1 in 100mM HEPES buffer[1]. ZnAF-1F is a Zn sensors in neutral and slightly acidic conditions[2]. |
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| References | [1]. Hirano T, et al. Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J Am Chem Soc. 2002 Jun 12;124(23):6555-62. [2]. Zhaohua Dai, et al. Tailoring tripodal ligands for zinc sensing. New J. Chem., 2007,31, 1708-1718. [3]. Que EL, et al. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chem Rev. 2008 May;108(5):1517-49. |
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Chemical & Physical Properties
| Density | 1.49g/cm3 |
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| Boiling Point | 822.1ºC at 760 mmHg |
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| Molecular Formula | C34H26F2N4O5 |
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| Molecular Weight | 608.59100 |
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| Flash Point | 451ºC |
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| Exact Mass | 608.18700 |
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| PSA | 128.79000 |
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| LogP | 6.22410 |
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| Index of Refraction | 1.715 |
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| InChIKey | PUDBCJSXTISPOO-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(NCCN(Cc2ccccn2)Cc2ccccn2)ccc1-c1c2cc(F)c(=O)cc-2oc2cc(O)c(F)cc12 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Articles1
More Articles
| Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J. Am. Chem. Soc. 124 , 6555-6562, (2002) The development and cellular applications of novel fluorescent probes for Zn2+, ZnAF-1F, and ZnAF-2F are described. Fluorescein is used as a fluorophore of ZnAFs, because its excitation and emission w... | |
Synonyms
| ZnAF-1F |
| 5-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2',7'-difluorofluorescein |
