Introduction：Basic information about CAS 61966-08-3|Phosphate Salt of Tricyclic Nucleoside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Phosphate Salt of Tricyclic Nucleoside |
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| CAS Number | 61966-08-3 | Molecular Weight | 400.28 |
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| Density | 2.2±0.1 g/cm3 | Boiling Point | 832.8±75.0 °C at 760 mmHg |
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| Molecular Formula | C13H17N6O7P | Melting Point | / |
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| MSDS | / | Flash Point | 457.4±37.1 °C |
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Names
| Name | triciribine phosphate |
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| Synonym | More Synonyms |
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Phosphate Salt of Tricyclic Nucleoside BiologicalActivity
| Description | Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>ATP Synthase |
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| References | [1]. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22. |
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Chemical & Physical Properties
| Density | 2.2±0.1 g/cm3 |
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| Boiling Point | 832.8±75.0 °C at 760 mmHg |
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| Molecular Formula | C13H17N6O7P |
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| Molecular Weight | 400.28 |
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| Flash Point | 457.4±37.1 °C |
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| Exact Mass | 400.089630 |
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| PSA | 200.81000 |
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| LogP | -2.83 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.925 |
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| InChIKey | URLYINUFLXOMHP-HTVVRFAVSA-N |
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| SMILES | CN1N=C(N)c2cn(C3OC(COP(=O)(O)O)C(O)C3O)c3ncnc1c23 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RY8450000
- CHEMICAL NAME :
- 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D- ribofuranosyl)-
- CAS REGISTRY NUMBER :
- 61966-08-3
- LAST UPDATED :
- 198605
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C13-H17-N6-O7-P
- MOLECULAR WEIGHT :
- 400.33
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 193 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 109 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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Synonyms
| 5-Methyl-1-(5-O-phosphono-b-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| 5-Methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Pentaazaacenaphthylene-5' phosphate ester |
| 3-Amino-1,5-dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(Dihydrogen Phosphate) |
| Phosphate Salt of Tricyclic Nucleoside |
| Triciribine phosphate (USAN) |
| 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)- |
| VQD-002 |
| TCN-P |
