CAS 137888-11-0|Carmoterol hydrochloride

Introduction：Basic information about CAS 137888-11-0|Carmoterol hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Carmoterol hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Carmoterol hydrochloride
CAS Number	137888-11-0	Molecular Weight	404.887
Density	/	Boiling Point	649.1ºC at 760mmHg
Molecular Formula	C₂₁H₂₅ClN₂O₄	Melting Point	/
MSDS	/	Flash Point	346.4ºC

Names

Name	Carmoterol Hydrochloride
Synonym	More Synonyms

Carmoterol hydrochloride BiologicalActivity

Description	Carmoterol hydrochloride is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology
References	[1]. Mario Cazzola, et al. β(2) -adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011 May;163(1):4-17. [2]. Giuseppe Rossoni, et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20(3):250-7.

Description

Carmoterol hydrochloride is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology

References

[1]. Mario Cazzola, et al. β(2) -adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011 May;163(1):4-17.

[2]. Giuseppe Rossoni, et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20(3):250-7.

Chemical & Physical Properties

Boiling Point	649.1ºC at 760mmHg
Molecular Formula	C₂₁H₂₅ClN₂O₄
Molecular Weight	404.887
Flash Point	346.4ºC
Exact Mass	404.150299
PSA	94.58000
LogP	3.68940

Synonyms

8-Hydroxy-5-((1R)-1-hydroxy-2-(N-(1R)-2-(p-methoxyphenyl)isopropylamino)ethyl)carbostyril HCl

8-Hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)-2-propanyl]amino}ethyl]-2(1H)-quinolinone hydrochloride (1:1)

Carmoterol hydrochloride

8-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one hydrochloride

2(1H)-Quinolinone, 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-, hydrochloride (1:1)

8-Hydroxy-5-(1-hydroxy-2-(N-(2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril hydrochloride

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