CAS 31528-44-6|Mycophenolic Acid β-D-Glucuronide
Introduction：Basic information about CAS 31528-44-6|Mycophenolic Acid β-D-Glucuronide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mycophenolic Acid β-D-Glucuronide | ||
|---|---|---|---|
| CAS Number | 31528-44-6 | Molecular Weight | 496.46100 |
| Density | 1.502g/cm3 | Boiling Point | 875.7ºC at 760mmHg |
| Molecular Formula | C23H28O12 | Melting Point | 98-100ºC |
| MSDS | / | Flash Point | 299.6ºC |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | mycophenolic acid glucuronide |
|---|---|
| Synonym | More Synonyms |
Mycophenolic Acid β-D-Glucuronide BiologicalActivity
| Description | Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | Mycophenolic acid glucuronide shows weak IMP dehydrogenase (IMPDH) type II inhibition with an IC50 of 3.3 mg/L[3]. |
| In Vivo | Mycophenolic acid glucuronide (intraperitoneal injection; 6 mg/mouse; once two days; 6 d) treatment reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model[2]. Animal Model: Swiss albino strain mouse implanted with Ehrlich ascites tumor cells[2] Dosage: 6 mg/mouse Administration: Intraperitoneal injection; 6 mg/mouse; once two days; 6 d Result: Showed 76.8% tumor inhibition compared to the untreated control. |
| References | [1]. Natascha A Wolff, et al. Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. Nephrol Dial Transplant. 2007 Sep;22(9):2497-503. [2]. Ando K, et al. Synthesis of mycophenolic acid beta-D-glucuronide and its antitumor activity. J Antibiot (Tokyo). 1970 Aug;23(8):408-13. [3]. Gensburger O, et al. Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase. Clin Chem. 2009 May;55(5):986-93. |
Chemical & Physical Properties
| Density | 1.502g/cm3 |
|---|---|
| Boiling Point | 875.7ºC at 760mmHg |
| Melting Point | 98-100ºC |
| Molecular Formula | C23H28O12 |
| Molecular Weight | 496.46100 |
| Flash Point | 299.6ºC |
| Exact Mass | 496.15800 |
| PSA | 189.28000 |
| LogP | 0.29860 |
| Index of Refraction | 1.624 |
| InChIKey | BYFGTSAYQQIUCN-UHFFFAOYSA-N |
| SMILES | COc1c(C)c2c(c(OC3OC(C(=O)O)C(O)C(O)C3O)c1CC=C(C)CCC(=O)O)C(=O)OC2 |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235 |
| Hazard Codes | F,Xn |
| Risk Phrases | 11-20/21/22-36 |
| Safety Phrases | 16-26-36/37 |
| RIDADR | UN 1648 3 / PGII |
Synonyms
| 5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl b-D-Glucopyranosiduronic Acid |
| MYCOPHENOLIC ACID B-D-GLUCURONIDE |
| Mycophenolic Acid-D-Glucuronide |
| Mycophenolic Acid Glucosiduronate |
| 5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl-D-Glucopyranosiduronic Acid |
