CAS 61837-65-8|(+/-)-4-Hydroxy Mephenytoin
| Common Name | (+/-)-4-Hydroxy Mephenytoin | ||
|---|---|---|---|
| CAS Number | 61837-65-8 | Molecular Weight | 234.251 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C12H14N2O3 | Melting Point | 153-154ºC |
| MSDS | ChineseUSA | Flash Point | 48.2 °F |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | (+/-)-4-Hydroxy Mephenytoin |
|---|---|
| Synonym | More Synonyms |
(+/-)-4-Hydroxy Mephenytoin BiologicalActivity
| Description | 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| In Vitro | 4-Hydroxymephenytoin is a metabolism of mephenytoin, which is an antiepileptic drug, and used as a CYP2C19 substrate[1]. 4-Hydroxymephenytoin (4'-Hydroxymephenytoin) is used for developing UltraPerformance LC (UPLC) tandem mass spectrometry assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples[2]. |
| References | [1]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94. [2]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 153-154ºC |
| Molecular Formula | C12H14N2O3 |
| Molecular Weight | 234.251 |
| Exact Mass | 234.100449 |
| PSA | 69.64000 |
| LogP | 0.66 |
| Index of Refraction | 1.568 |
| InChIKey | OQPLORUDZLXXPD-UHFFFAOYSA-N |
| SMILES | CCC1(c2ccc(O)cc2)NC(=O)N(C)C1=O |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol |
| Flash Point(F) | 48.2 °F |
| Flash Point(C) | 9 °C |
Articles35
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| Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations. Nanoscale Res. Lett. 9(1) , 642, (2014) Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms ... | |
| Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method. Rapid Commun. Mass Spectrom. 18(15) , 1675-80, (2004) A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method without the use of sample extraction was developed for the simultaneous quantification of urinary concentrat... |
Synonyms
| 4-hydroxy mephenytoin |
| 5-Ethyl-5-(4-hydroxyphenyl)-3-methyl-2,4-imidazolidinedione |
| 5-Ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione |
| 2,4-Imidazolidinedione, 5-ethyl-5-(4-hydroxyphenyl)-3-methyl- |
| 4-Hydroxymephenytoin |
