Introduction：Basic information about CAS 139755-82-1|N-Desmethyl Sildenafil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-Desmethyl Sildenafil |
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| CAS Number | 139755-82-1 | Molecular Weight | 460.55 |
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| Density | 1.44g/cm3 | Boiling Point | 685.7ºC at 760 mmHg |
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| Molecular Formula | C21H28N6O4S | Melting Point | 158-160ºC |
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| MSDS | / | Flash Point | 368.5ºC |
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Names
| Name | N-Desmethyl Sildenafil |
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| Synonym | More Synonyms |
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N-Desmethyl Sildenafil BiologicalActivity
| Description | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE) |
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| In Vitro | N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1]. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2]. |
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| References | [1]. Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. [2]. Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. |
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Chemical & Physical Properties
| Density | 1.44g/cm3 |
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| Boiling Point | 685.7ºC at 760 mmHg |
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| Melting Point | 158-160ºC |
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| Molecular Formula | C21H28N6O4S |
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| Molecular Weight | 460.55 |
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| Flash Point | 368.5ºC |
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| Exact Mass | 460.18900 |
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| PSA | 130.59000 |
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| LogP | 2.61620 |
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| Vapour Pressure | 1.17E-18mmHg at 25°C |
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| Index of Refraction | 1.683 |
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Synonyms
| 5-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one |
