CAS 614-60-8|2-Hydroxycinnamic acid
| Common Name | 2-Hydroxycinnamic acid | ||
|---|---|---|---|
| CAS Number | 614-60-8 | Molecular Weight | 164.158 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 348.0±17.0 °C at 760 mmHg |
| Molecular Formula | C9H8O3 | Melting Point | 217ºC |
| MSDS | ChineseUSA | Flash Point | 178.5±17.4 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 2-Hydroxy Cinnamic Acid |
|---|---|
| Synonym | More Synonyms |
2-Hydroxycinnamic acid BiologicalActivity
| Description | 2-Hydroxycinnamic acid is isolated from the methanol extract of Cinnamomum cassia. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM[2] |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoV |
| Target | HIV |
| References | [1]. Tran Minh Ngoc, et al. A new coumarin and cytotoxic activities of constituents from Cinnamomum cassia. Nat Prod Commun. 2014 Apr;9(4):487-8. [2]. Min Zhuang, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009 Apr;82(1):73-81. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 348.0±17.0 °C at 760 mmHg |
| Melting Point | 217ºC |
| Molecular Formula | C9H8O3 |
| Molecular Weight | 164.158 |
| Flash Point | 178.5±17.4 °C |
| Exact Mass | 164.047348 |
| PSA | 57.53000 |
| LogP | 2.43 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.660 |
| InChIKey | PMOWTIHVNWZYFI-AATRIKPKSA-N |
| SMILES | O=C(O)C=Cc1ccccc1O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02587
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant;Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S24/25-S36 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | GD9090000 |
Articles13
More Articles| Antimicrobial activity of natural products from the flora of Northern Ontario, Canada. Pharm. Biol. 53(6) , 800-6, (2015) The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ... | |
| Soluble and cell wall-bound phenolic acids and ferulic acid dehydrodimers in rye flour and five bread model systems: insight into mechanisms of improved availability. J. Sci. Food Agric. 95(5) , 1103-15, (2015) The bread-making process influences bread components, including phenolics that significantly contribute to its antioxidant properties. Five bread model systems made from different rye cultivars were i... | |
| Effect of enzymatic pretreatment of various lignocellulosic substrates on production of phenolic compounds and biomethane potential. Bioresour. Technol. 192 , 696-702, (2015) Pretreatment of lignocellulosic biomass is necessary to enhance the hydrolysis, which is the rate-limiting step in biogas production. Laccase and versatile peroxidase are enzymes known to degrade lign... |
Synonyms
| (2E)-3-(2-Hydroxyphenyl)-2-propenoic acid |
| (2E)-3-(2-Hydroxyphenyl)acrylic acid |
| (E)-o-coumaric acid |
| trans-2-coumaric acid |
| o-Coumaric acid |
| (E)-3-(2-Hydroxyphenyl)-2-propenoic acid |
| Cinnamic acid, o-hydroxy-, (E)- |
| Coumaric acid |
| 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)- |
| o-Hydroxy-trans-cinnamic acid |
| 2-Hydroxycinnamic acid, (E)- |
| QV1U1R BQ &&E or trans Form |
| (E)-3-(2-Hydroxyphenyl)acrylic acid |
| Cinnamic acid, o-hydroxy- |
| 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (2E)- |
| (2E)-3-(2-Hydroxyphenyl)prop-2-enoic acid |
| EINECS 210-386-4 |
| trans-2-Hydroxycinnamic acid |
| trans-o-Coumaric Acid |
| trans-o-Hydroxycinnamic acid |
| o-Hydroxycinnamic acid |
| 2-Hydroxycinnamic acid |
| (E)-2-Hydroxycinnamic acid |
| (E)-o-Hydroxycinnamic acid |
| (E)-3-(2-Hydroxyphenyl)prop-2-enoic acid |
| MFCD00004379 |
| ortho-Hydroxycinnamic acid |
