Introduction：Basic information about CAS 130018-77-8|Levocetirizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Levocetirizine |
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| CAS Number | 130018-77-8 | Molecular Weight | 388.888 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 542.1±45.0 °C at 760 mmHg |
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| Molecular Formula | C21H25ClN2O3 | Melting Point | 205-208°C (dec.) |
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| MSDS | / | Flash Point | 281.6±28.7 °C |
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Names
| Name | Levocetirizine |
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| Synonym | More Synonyms |
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Levocetirizine BiologicalActivity
| Description | Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. |
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| Related Catalog | Research Areas >>Endocrinology |
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| Target | H1 receptor |
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| In Vivo | Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1]. Animal Model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g)[1] Dosage: 0.4 mg/kg Administration: Oral administration (Pharmacokinetic Analysis) Result: The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively. |
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| References | [1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 542.1±45.0 °C at 760 mmHg |
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| Melting Point | 205-208°C (dec.) |
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| Molecular Formula | C21H25ClN2O3 |
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| Molecular Weight | 388.888 |
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| Flash Point | 281.6±28.7 °C |
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| Exact Mass | 388.155365 |
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| PSA | 53.01000 |
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| LogP | 2.16 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.589 |
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| InChIKey | ZKLPARSLTMPFCP-OAQYLSRUSA-N |
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| SMILES | O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 |
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| Storage condition | -20°C Freezer |
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 2933599090 |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Levocetirizine [INN] |
| vardenafilH |
| Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)- |
| Vivanza |
| MFCD04112703 |
| levocarnitine |
| (2-(4-((R)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid |
| Vardenafil |
| (-)-Cetirizine |
| levocetirizinum |
| Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- |
| (R)-Cetirizine |
| Levocetirizine |
