CAS 786686-79-1|Olanzapine D3

Introduction：Basic information about CAS 786686-79-1|Olanzapine D3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Olanzapine D3 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Olanzapine D3
CAS Number	786686-79-1	Molecular Weight	315.45100
Density	1.337g/cm3	Boiling Point	476.035ºC at 760 mmHg
Molecular Formula	C₁₇H₁₇D₃N₄S	Melting Point	188-190ºC
MSDS	/	Flash Point	241.697ºC

Names

Name	2-methyl-4-[4-(trideuteriomethyl)piperazin-1-yl]-5H-thieno[3,2-c][1,5]benzodiazepine
Synonym	More Synonyms

Olanzapine D3 BiologicalActivity

Description	Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is 5-HT2 and D1/D2 antagonist. Olanzapine is an antipsychotic agent with anticholinergic properties[1]. Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line[2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorSignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
References	[1]. Moore NA, et al. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51. [2]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.

Description

Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is 5-HT2 and D1/D2 antagonist. Olanzapine is an antipsychotic agent with anticholinergic properties[1]. Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line[2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorSignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor

References

[1]. Moore NA, et al. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51.

[2]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.

Chemical & Physical Properties

Density	1.337g/cm3
Boiling Point	476.035ºC at 760 mmHg
Melting Point	188-190ºC
Molecular Formula	C₁₇H₁₇D₃N₄S
Molecular Weight	315.45100
Flash Point	241.697ºC
Exact Mass	315.16000
PSA	59.11000
LogP	2.88860
Index of Refraction	1.709

Synonyms

Olanzapine-methyl-d3

2-methyl-4-(4-methyl-D3-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine

Oliza-d3

Oltal-d3

Integrol-d3

Zyprexa-d3

Olanzapine-d3

Oleanz-d3

Lanzac-d3

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