CAS 78739-01-2|D-AP4

Introduction：Basic information about CAS 78739-01-2|D-AP4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. D-AP4 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	D-AP4
CAS Number	78739-01-2	Molecular Weight	183.10000
Density	1.628g/cm3	Boiling Point	491.7ºC at 760 mmHg
Molecular Formula	C₄H₁₀NO₅P	Melting Point	212-213ºC
MSDS	/	Flash Point	251.2ºC

Names

Name	d-ap4
Synonym	More Synonyms

D-AP4 BiologicalActivity

Description	D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM)[1][2][3].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
References	[1]. Evans RH, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982;75(1):65-75. [2]. Schulte MK, et al. Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994;649(1-2):203-207. [3]. Toms NJ, et al. Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells. Neuropharmacology. 1997;36(3):335-343.

Description

D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM)[1][2][3].

Related Catalog

Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR

References

[1]. Evans RH, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982;75(1):65-75.

[2]. Schulte MK, et al. Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994;649(1-2):203-207.

[3]. Toms NJ, et al. Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells. Neuropharmacology. 1997;36(3):335-343.

Chemical & Physical Properties

Density	1.628g/cm3
Boiling Point	491.7ºC at 760 mmHg
Melting Point	212-213ºC
Molecular Formula	C₄H₁₀NO₅P
Molecular Weight	183.10000
Flash Point	251.2ºC
Exact Mass	183.03000
PSA	130.66000
Index of Refraction	1.545
InChIKey	DDOQBQRIEWHWBT-GSVOUGTGSA-N
SMILES	NC(CCP(=O)(O)O)C(=O)O

Safety Information

Safety Phrases	S24/25

Synonyms

1-Phenyl-2,2,2-trifluorethanol

dl-2,2,2-trifluoro-1-phenylethanol

D-2-amino-4-phosphonobutanoic acid

2,2,2-TRIFLUORO-1-PHENYL-1-ETHANOL

(R)-2-amino-4-phosphonobutanoic acid

MFCD00083243

1,1,1-trifluoro-2-phenyl-2-ethanol

1-hydroxy-2,2,2-trifluoroethyl-benzene

2,2,2-trifluoro-1-phenylethanol

2,2,2-trifluorophenethyl alcohol

R(-)-1-phenyl-2,2,2-trifluoroethanol

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