Introduction：Basic information about CAS 391210-00-7|PD318088, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PD318088 |
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| CAS Number | 391210-00-7 | Molecular Weight | 561.089 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C16H13BrF3IN2O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide |
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| Synonym | More Synonyms |
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PD318088 BiologicalActivity
| Description | PD318088 is an allosteric MEK inhibitor. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | MEK |
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| References | [1]. Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. [2]. Han S, et al. Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73. |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Molecular Formula | C16H13BrF3IN2O4 |
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| Molecular Weight | 561.089 |
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| Exact Mass | 559.905518 |
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| PSA | 94.31000 |
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| LogP | 7.43 |
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| Index of Refraction | 1.660 |
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| InChIKey | XXSSGBYXSKOLAM-UHFFFAOYSA-N |
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| SMILES | O=C(NOCC(O)CO)c1cc(Br)c(F)c(F)c1Nc1ccc(I)cc1F |
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| Storage condition | -20℃ |
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Synonyms
| cc-457 |
| C16H13BrF3IN2O4 |
| 5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide |
| S1568_Selleck |
| Benzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- |
| PD318088 |
