Introduction：Basic information about CAS 924296-18-4|DUBs-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DUBs-IN-1 |
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| CAS Number | 924296-18-4 | Molecular Weight | 337.33400 |
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| Density | 1.32g/cm3 | Boiling Point | 632.2ºC at 760 mmHg |
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| Molecular Formula | C20H11N5O | Melting Point | / |
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| MSDS | / | Flash Point | 336.2ºC |
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Names
| Name | 9-[(Benzyloxy)imino]-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
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| Synonym | More Synonyms |
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DUBs-IN-1 BiologicalActivity
| Description | DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>DeubiquitinaseResearch Areas >>Cancer |
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| Target | IC50: 0.24 μM (USP8)[1] |
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| In Vitro | DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1]. |
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| References | [1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8. |
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Chemical & Physical Properties
| Density | 1.32g/cm3 |
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| Boiling Point | 632.2ºC at 760 mmHg |
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| Molecular Formula | C20H11N5O |
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| Molecular Weight | 337.33400 |
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| Flash Point | 336.2ºC |
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| Exact Mass | 337.09600 |
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| PSA | 94.95000 |
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| LogP | 3.16956 |
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| Index of Refraction | 1.704 |
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| InChIKey | GKOWDIBLCDZJHF-UHFFFAOYSA-N |
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| SMILES | N#Cc1nc2c(nc1C#N)-c1ccccc1C2=NOCc1ccccc1 |
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Synonyms
