Introduction：Basic information about CAS 139504-50-0|Mertansine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mertansine |
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| CAS Number | 139504-50-0 | Molecular Weight | 738.288 |
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| Density | 1.33±0.1 g/cm3 | Boiling Point | 937.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C35H48ClN3O10S | Melting Point | 190-192 ºC |
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| MSDS | / | Flash Point | 520.5±34.3 °C |
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Names
| Name | Mertansine |
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| Synonym | More Synonyms |
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Mertansine BiologicalActivity
| Description | Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. |
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| Related Catalog | Signaling Pathways >>Antibody-drug Conjugate >>Drug-Linker Conjugates for ADCSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/TubulinResearch Areas >>Cancer |
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| References | [1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. |
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Chemical & Physical Properties
| Density | 1.33±0.1 g/cm3 |
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| Boiling Point | 937.1±65.0 °C at 760 mmHg |
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| Melting Point | 190-192 ºC |
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| Molecular Formula | C35H48ClN3O10S |
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| Molecular Weight | 738.288 |
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| Flash Point | 520.5±34.3 °C |
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| Exact Mass | 737.274902 |
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| PSA | 198.76000 |
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| LogP | 4.76 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.599 |
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| InChIKey | ANZJBCHSOXCCRQ-OQIPERMCSA-N |
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| SMILES | COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCS)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2 |
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| Storage condition | -20℃ |
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| Water Solubility | Insuluble (2.4E-4 g/L) (25 ºC) |
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Synonyms
| UNII-DDZ29HGH0E |
| DM1 Compound |
| DM1 [Maytansinoid] |
| (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2 S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate (non-preferred name) |
| Maytansine,N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl) |
| DM 1 |
| Mertansine |
| maytansinoid DM1 |
| N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine |
| maytansinoid DM 1 |
| N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine |
