Introduction：Basic information about CAS 16836-31-0|Kauran-16,17-diol (ent-Kauran-16beta,17-diol), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kauran-16,17-diol (ent-Kauran-16beta,17-diol) |
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| CAS Number | 16836-31-0 | Molecular Weight | 306.48300 |
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| Density | 1.09g/cm3 | Boiling Point | 422.3ºC at 760mmHg |
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| Molecular Formula | C20H34O2 | Melting Point | / |
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| MSDS | / | Flash Point | 186.8ºC |
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Names
| Name | Kauran-16,17-diol |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology |
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| In Vitro | Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1]. |
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| References | [1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8. |
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Chemical & Physical Properties
| Density | 1.09g/cm3 |
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| Boiling Point | 422.3ºC at 760mmHg |
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| Molecular Formula | C20H34O2 |
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| Molecular Weight | 306.48300 |
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| Flash Point | 186.8ºC |
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| Exact Mass | 306.25600 |
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| PSA | 40.46000 |
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| LogP | 4.14260 |
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| Vapour Pressure | 6.7E-09mmHg at 25°C |
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| Index of Refraction | 1.55 |
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| InChIKey | LCYWCTWYVKIBSA-ZYLYKIMZSA-N |
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| SMILES | CC1(C)CCCC2(C)C1CCC13CC(CCC12)C(O)(CO)C3 |
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| Storage condition | 2-8℃ |
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Synonyms
| Ent-kauran-16,17-diol |
| Kaurane-16,17-diol |
| (5beta,9beta,10alpha,16beta)-Kaurane-16,17-Diol |
