Introduction：Basic information about CAS 168682-53-9|ezatiostat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ezatiostat |
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| CAS Number | 168682-53-9 | Molecular Weight | 529.648 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 749.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H35N3O6S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 407.2±32.9 °C |
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Names
| Name | ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate |
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| Synonym | More Synonyms |
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ezatiostat BiologicalActivity
| Description | Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1). |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Gutathione S-transferaseResearch Areas >>Cancer |
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| In Vitro | Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1]. |
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| References | [1]. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 749.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H35N3O6S |
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| Molecular Weight | 529.648 |
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| Flash Point | 407.2±32.9 °C |
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| Exact Mass | 529.224670 |
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| PSA | 169.10000 |
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| LogP | 4.27 |
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| Appearance of Characters | white solid |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.569 |
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| InChIKey | GWEJFLVSOGNLSS-WPFOTENUSA-N |
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| SMILES | CCOC(=O)C(N)CCC(=O)NC(CSCc1ccccc1)C(=O)NC(C(=O)OCC)c1ccccc1 |
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| Storage condition | -20℃ |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate |
| Ter-199 |
| TLK-199 |
| ezatiostat |
| UNII-057D10I8S8 |
| Telintra |
| Terrapin 199 |
