CAS 13189-98-5|Fudosteine

Introduction：Basic information about CAS 13189-98-5|Fudosteine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fudosteine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Fudosteine
CAS Number	13189-98-5	Molecular Weight	179.237
Density	1.3±0.1 g/cm3	Boiling Point	354.5±42.0 °C at 760 mmHg
Molecular Formula	C₆H₁₃NO₃S	Melting Point	210.9-212.5ºC
MSDS	/	Flash Point	168.2±27.9 °C

Names

Name	Fudosteine
Synonym	More Synonyms

Fudosteine BiologicalActivity

Description	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.Target: OthersFudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. The administration of fudosteine during the challenge with ovalbumin prevented the development of airway hyperresponsiveness and accumulation of lymphocytes in the airways. Eotaxin, IL-4, and TGF-β levels and the relative intensity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9) in BAL fluid were reduced by the fudosteine treatment; however, the number of eosinophils in BAL fluid and serum IgE levels did not change. The expression of TGF-β, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduced by the fudosteine treatment [1]. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro [2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References	[1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23. [2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202.

Description

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.Target: OthersFudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. The administration of fudosteine during the challenge with ovalbumin prevented the development of airway hyperresponsiveness and accumulation of lymphocytes in the airways. Eotaxin, IL-4, and TGF-β levels and the relative intensity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9) in BAL fluid were reduced by the fudosteine treatment; however, the number of eosinophils in BAL fluid and serum IgE levels did not change. The expression of TGF-β, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduced by the fudosteine treatment [1]. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro [2].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease

References

[1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23.

[2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	354.5±42.0 °C at 760 mmHg
Melting Point	210.9-212.5ºC
Molecular Formula	C₆H₁₃NO₃S
Molecular Weight	179.237
Flash Point	168.2±27.9 °C
Exact Mass	179.061615
PSA	108.85000
LogP	-0.10
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.558
InChIKey	KINWYTAUPKOPCQ-YFKPBYRVSA-N
SMILES	NC(CSCCCO)C(=O)O
Storage condition	-20°C Freezer

Safety Information

Hazard Codes	Xi

Synonyms

FUDESTEINE

fudosteine

S-(3-Hydroxypropyl)-L-cysteine

L-Cysteine, S-(3-hydroxypropyl)-

MFCD00899873

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