Introduction：Basic information about CAS 130288-24-3|Duocarmycin SA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Duocarmycin SA |
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| CAS Number | 130288-24-3 | Molecular Weight | 477.46600 |
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| Density | 1.53±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C25H23N3O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (+)-duocarmycin SA |
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| Synonym | More Synonyms |
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Duocarmycin SA BiologicalActivity
| Description | Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Cytotoxin |
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| References | [1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [2]. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692. |
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Chemical & Physical Properties
| Density | 1.53±0.1 g/cm3 |
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| Molecular Formula | C25H23N3O7 |
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| Molecular Weight | 477.46600 |
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| Exact Mass | 477.15400 |
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| PSA | 122.95000 |
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| LogP | 2.74020 |
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| Vapour Pressure | 8.82E-25mmHg at 25°C |
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| InChIKey | VQNATVDKACXKTF-XELLLNAOSA-N |
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| SMILES | COC(=O)c1cc2c([nH]1)C(=O)C=C1N(C(=O)c3cc4cc(OC)c(OC)c(OC)c4[nH]3)CC3CC123 |
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| Water Solubility | Practically insoluble (0.03 g/L) (25 ºC) |
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Synonyms
| Duocarmycin SA |
| Antibiotic DC 113 |
