Introduction：Basic information about CAS 137234-71-0|Voriconazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Voriconazole |
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| CAS Number | 137234-71-0 | Molecular Weight | 581.607 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H30F3N5O5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate |
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| Synonym | More Synonyms |
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Voriconazole BiologicalActivity
| Description | Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
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| In Vitro | Voriconazole camphorsulfonate has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125–0.25 μg/mL, respectively[1]. Voriconazole camphorsulfonate inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth[2]. |
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| In Vivo | Voriconazole (5-20 mg/kg; p.o. for 21 days) camphorsulfonate prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) camphorsulfonate decreases the fungal burden in the lungs[3]. Animal Model: Male specific-pathogen-free BALB/cByJ mice[3] Dosage: 1, 5, 20 mg/kg/day Administration: P.o. once daily for 21 days Result: Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively. |
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| References | [1]. Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8. [2]. Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67(2):269-98. [3]. A M Sugar,et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45(2):601-4. |
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Chemical & Physical Properties
| Molecular Formula | C26H30F3N5O5S |
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| Molecular Weight | 581.607 |
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| Exact Mass | 581.191956 |
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| PSA | 156.54000 |
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| LogP | 4.52730 |
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Synonyms
| voriconazole |
| [(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid - (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1:1) |
| Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)-, compd. with (αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidine 
ethanol (1:1) |
| voriconazole (1r)-(-)-10-camphorsulfonate |
| (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol l(-)-camphorsulfonate |
| (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-oll-(-)-10-camphorsulfonate |
