CAS 132112-35-7|Ropivacaine hydrochloride

Introduction：Basic information about CAS 132112-35-7|Ropivacaine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ropivacaine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Ropivacaine hydrochloride
CAS Number	132112-35-7	Molecular Weight	328.88
Density	1.0±0.1 g/cm3	Boiling Point	410.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₉ClN₂O₂	Melting Point	267-269ºC
MSDS	ChineseUSA	Flash Point	201.9±28.7 °C
Symbol	GHS05	Signal Word	Danger

Names

Name	(S)-ropivacaine hydrochloride hydrate
Synonym	More Synonyms

Ropivacaine hydrochloride BiologicalActivity

Description	Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease
References	[1]. Cederholm, I., S. Anskar, and M. Bengtsson, Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth, 1994. 19(1): p. 18-33. [2]. Oda, Y., et al., Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology, 1995. 82(1): p. 214-20.

Description

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease

References

[1]. Cederholm, I., S. Anskar, and M. Bengtsson, Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth, 1994. 19(1): p. 18-33.

[2]. Oda, Y., et al., Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology, 1995. 82(1): p. 214-20.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	410.2±45.0 °C at 760 mmHg
Melting Point	267-269ºC
Molecular Formula	C₁₇H₂₉ClN₂O₂
Molecular Weight	328.88
Flash Point	201.9±28.7 °C
PSA	41.57000
LogP	3.11
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.552
InChIKey	VSHFRHVKMYGBJL-CKUXDGONSA-N
SMILES	CCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl.O
Storage condition	Refrigerator

Safety Information

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338 + P310
Hazard Codes	T: Toxic;
Risk Phrases	R26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

(S)-ROPIVACAINE HCL

(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide

(S)-ROPIVACAINE HYDROCHLORIDE

(S)ROPIVACAINE HYDROCHLORIDE

(S)-ROPIVACAINEHYDROCHLORIDE

UNII-V910P86109

(-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide

Ropivacaine

Ropivacaine hydrochloride Monohydrate

(S)ROPIVACAINE HY DROCHLORIDE

2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-, hydrochloride, hydrate (1:1:1)

S-ROPIVACAINE HCL

Ropivacaine (hydrochloride Monohydrate)

(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide

(+-)-ropivacaine hydrochloride

(S)-ROPIVACAINEHCL

(S)-(-)-1-propyl-2',6'-pipecoloxylidide

S-ROPIVACAINEHCL

2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-

Ropivacainehydrochloride

Ropivacaine hydrochloride

(S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate

l-N-n-Propylpipecolic acid-2,6-xylidide

(-)-1-Propyl-2',6'-pipecoloxylidide

UNII-7IO5LYA57N

(S)-ropivacaine hydrochloride hydrate

(S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide

ropivacaine hydrochloride hydrate

Ropivacaine HCl.H2O

Ropivacaine HCl

S-ROPIVACAINE HYDROCHLORIDE

(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride hydrate

(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate

MFCD02102164

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