CAS 13422-51-0|Hydroxocobalamin
| Common Name | Hydroxocobalamin | ||
|---|---|---|---|
| CAS Number | 13422-51-0 | Molecular Weight | 1346.36 |
| Density | / | Boiling Point | / |
| Molecular Formula | C62H89CoN13O15P | Melting Point | 200ºC (decomposes) |
| MSDS | / | Flash Point | / |
Names
| Name | hydroxocobalamin |
|---|---|
| Synonym | More Synonyms |
Hydroxocobalamin BiologicalActivity
| Description | Hydroxocobalamin (Vitamin B12a) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65. |
Chemical & Physical Properties
| Melting Point | 200ºC (decomposes) |
|---|---|
| Molecular Formula | C62H89CoN13O15P |
| Molecular Weight | 1346.36 |
| Exact Mass | 1345.567017 |
| PSA | 484.10000 |
| LogP | 6.43870 |
| InChIKey | DQOCFCZRZOAIBN-YHKGLSPZSA-L |
| SMILES | CC1=C2N=C(C=C3N=C(C(C)=C4[N-]C(C)(C5N=C1C(C)(CCC(=O)NCC(C)OP(=O)([O-])OC1C(CO)OC(n6cnc7cc(C)c(C)cc76)C1O)C5CC(N)=O)C(C)(CC(N)=O)C4CCC(N)=O)C(C)(CC(N)=O)C3CCC(N)=O)C(C)(C)C2CCC(N)=O.O.[Co+2] |
| Storage condition | 2-8°C |
| Water Solubility | methanol: 10 mg/mL at 20 °C, clear, dark red |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,867,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3794 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3157 (estimated) No. of Female Employees: 1154 (estimated)
Safety Information
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GG3820000 |
Articles41
More Articles| Pseudo-blood leak? A hemodialysis mystery. Clin. Nephrol. 79(4) , 323-5, (2013) Hydroxocobalamin is a treatment for cyanide toxicity with few side effects. We report a case of a hemodialysis patient whose treatment was compromised by hydroxocobalamin interference with the blood l... | |
| A patient with an inborn error of vitamin B12 metabolism (cblF) detected by newborn screening. Pediatrics 132(1) , e257-61, (2013) A neonate, who was found to have an elevated C3/C2 ratio and minimally elevated propionylcarnitine on newborn screening, was subsequently identified as having the rare cblF inborn error of vitamin B12... | |
| Severe combined immunodeficiency resulting from mutations in MTHFD1. Pediatrics 131(2) , e629-34, (2013) Folate and vitamin B(12) metabolism are essential for de novo purine synthesis, and several defects in these pathways have been associated with immunodeficiency. Here we describe the occurrence of sev... |
Synonyms
| Hydroxocobalamin |
| Vitamin B12a acetate |
| EINECS 236-533-2 |
| hydroxycobalamin |
| ohb12 |
| vitamin B12a |
| duradoce |
| cobalex |
| docevita |
| MFCD00082532 |
| docclan |
| hydroxycobalamine |
| docelan |
| vibeden |
| hydrovit |
| axlon |
| axion |
