CAS 1338-41-6|Span 60
Introduction：Basic information about CAS 1338-41-6|Span 60, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Span 60 | ||
|---|---|---|---|
| CAS Number | 1338-41-6 | Molecular Weight | 430.618 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 579.0±45.0 °C at 760 mmHg |
| Molecular Formula | C24H46O6 | Melting Point | 54-57 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 185.3±22.2 °C |
Names
| Name | Span 60 |
|---|---|
| Synonym | More Synonyms |
Span 60 BiologicalActivity
| Description | Sorbitan monooctadecanoate is a hydrophobic nonionic surfactant. Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, wetting and dispersing/suspending agents. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Murdan S, et al. Novel sorbitan monostearate organogels[J]. Journal of pharmaceutical sciences, 1999, 88(6): 608-614. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.0±45.0 °C at 760 mmHg |
| Melting Point | 54-57 °C(lit.) |
| Molecular Formula | C24H46O6 |
| Molecular Weight | 430.618 |
| Flash Point | 185.3±22.2 °C |
| Exact Mass | 430.329437 |
| PSA | 96.22000 |
| LogP | 7.13 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.497 |
| InChIKey | HVUMOYIDDBPOLL-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCCC(=O)OCC(O)C1OCC(O)C1O |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2730 gm/kg/2Y-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,315,1959 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 635 gm/kg
- SEX/DURATION :
- multigenerations
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- REFERENCE :
- JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1270 gm/kg
- SEX/DURATION :
- female 84 day(s) pre-mating - 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81999 No. of Facilities: 693 (estimated) No. of Industries: 15 No. of Occupations: 25 No. of Employees: 14579 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81999 No. of Facilities: 6199 (estimated) No. of Industries: 63 No. of Occupations: 72 No. of Employees: 189741 (estimated) No. of Female Employees: 71370 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | WG2933500 |
| HS Code | 34021300 |
Customs
| HS Code | 2932190090 |
|---|---|
| Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Synonyms
| EINECS 215-664-9 |
| Drewsorb 60 |
| 1,4-anhydro-6-O-octadecanoyl-D-glucitol |
| D-Glucitol, 1,4-anhydro-5-O-(1-oxooctadecyl)- |
| 1,4-Anhydro-D-glucitol 6-octadecanoate |
| SPAN(R) 60 |
| Arlacel 60 |
| SPAN(TM) 60 |
| Barchlor 16S |
| Durtan 60 |
| Glycomul S |
| 1,4-Anhydro-5-O-stearoyl-D-glucitol |
| D-Glucitol, 1,4-anhydro-, 6-octadecanoate |
| 1,4-Anhydro-D-glucitol, 6-octadecanoate |
| SPAN NO 60 |
| Span(rg 60 |
| Lonzest(R) SMS |
| Emsorb 2505 |
| UNII:NVZ4I0H58X |
| 1,4-Anhydro-6-O-stearoyl-D-glucitol |
| (Sorbitan Monostearate) |
| Sorbitan stearate Sorbitane monostearate |
| D-Glucitol, 1,4-anhydro-6-O-(1-oxooctadecyl)- |
| FEMA 3028 |
| Sorbitan Monostearate |
| MFCD00005366 |
