Introduction：Basic information about CAS 134031-86-0|2'-OMe-U Phosphoramidite, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-OMe-U Phosphoramidite |
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| CAS Number | 134031-86-0 | Molecular Weight | 760.81 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C40H49N4O9P | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile |
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| Synonym | More Synonyms |
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2'-OMe-U Phosphoramidite BiologicalActivity
| Description | 3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Molecular Formula | C40H49N4O9P |
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| Molecular Weight | 760.81 |
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| Exact Mass | 744.32900 |
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| PSA | 150.86000 |
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| LogP | 6.81958 |
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Synonyms
| 5′-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3′-O-(4,4′-dimethoxytrityl)thymidine |
| 2'-OMe-UPhosphoramidite |
| 5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine |
| 2'-OMe-U Phosphoramidite |
| DMT-dT-CE Reverse Phosphoramidite |
