CAS 133628-73-6|L-Aspartic acid β-(7-amido-4-methylcoumarin)
| Common Name | L-Aspartic acid β-(7-amido-4-methylcoumarin) | ||
|---|---|---|---|
| CAS Number | 133628-73-6 | Molecular Weight | 290.27100 |
| Density | 1.452g/cm3 | Boiling Point | 610ºC at 760mmHg |
| Molecular Formula | C14H14N2O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 322.7ºC |
Names
| Name | L-Aspartic acid β-(7-amido-4-methylcoumarin) |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Hatanaka T, et al. Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47. |
Chemical & Physical Properties
| Density | 1.452g/cm3 |
|---|---|
| Boiling Point | 610ºC at 760mmHg |
| Molecular Formula | C14H14N2O5 |
| Molecular Weight | 290.27100 |
| Flash Point | 322.7ºC |
| Exact Mass | 290.09000 |
| PSA | 122.63000 |
| LogP | 1.61520 |
| Vapour Pressure | 9.8E-16mmHg at 25°C |
| Index of Refraction | 1.651 |
| InChIKey | ARZPQBJTLVVDNP-JTQLQIEISA-N |
| SMILES | Cc1cc(=O)oc2cc(NC(=O)CC(N)C(=O)O)ccc12 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22 |
| RIDADR | NONH for all modes of transport |
Articles5
More Articles| Applications of a new fluorimetric enzyme assay for the diagnosis of aspartylglucosaminuria. J. Inherit. Metab. Dis. 16 , 929-934, (1993) L-Aspartic acid-beta-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylglucosaminidase). Fibroblasts and leukocytes from 8 patients wi... | |
| Structural basis of aspartylglucosaminuria. Biochem. Biophys. Res. Commun. 377 , 1168-1172, (2008) To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modelin... | |
| Enzymatic diagnosis of aspartylglycosaminuria by fluorometric assay of glycosylasparaginase in serum, plasma, or lymphocytes. Clin. Chem. 40 , 385-388, (1994) Serum, plasma, and lymphocytes from aspartylglycosaminuria (AGU) patients and carriers and from normal controls were incubated with a fluorescent glycosylasparaginase substrate, L-aspartic acid beta-(... |
Synonyms
| h-asp(amc)-oh |
