Introduction：Basic information about CAS 36622-28-3|(S)-Verapamil hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-Verapamil hydrochloride |
|---|
| CAS Number | 36622-28-3 | Molecular Weight | 491.06300 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C27H39ClN2O4 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | S(−)-Verapamil hydrochloride hydrate |
|---|
| Synonym | More Synonyms |
|---|
(S)-Verapamil hydrochloride BiologicalActivity
| Description | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1]. |
|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Leukotriene Receptor |
|---|
| Target | LTC4 Ca2+ |
|---|
| In Vitro | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1]. |
|---|
| References | [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309. |
|---|
Chemical & Physical Properties
| Molecular Formula | C27H39ClN2O4 |
|---|
| Molecular Weight | 491.06300 |
|---|
| Exact Mass | 490.26000 |
|---|
| PSA | 63.95000 |
|---|
| LogP | 5.89508 |
|---|
| InChIKey | DOQPXTMNIUCOSY-YCBFMBTMSA-N |
|---|
| SMILES | COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC.Cl |
|---|
Safety Information
Synonyms
| s(-)-verapamil |
| MFCD00069355 |
| EINECS 253-132-8 |
