CAS 134272-63-2|Mal-NH-Boc

Introduction：Basic information about CAS 134272-63-2|Mal-NH-Boc, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMal-NH-Boc
CAS Number134272-63-2Molecular Weight240.25600
Density/Boiling Point/
Molecular FormulaC11H16N2O4Melting Point110-115 °C
MSDS/Flash Point/

Names

Nametert-butyl N-[2-(2,5-dioxopyrrol-1-yl)ethyl]carbamate
SynonymMore Synonyms

Mal-NH-Boc BiologicalActivity

DescriptionMal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Alkyl/ether

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Melting Point110-115 °C
Molecular FormulaC11H16N2O4
Molecular Weight240.25600
Exact Mass240.11100
PSA75.71000
LogP0.76490
InChIKeySNYRFQCLCLMCCG-UHFFFAOYSA-N
SMILESCC(C)(C)OC(=O)NCCN1C(=O)C=CC1=O

Safety Information

Hazard CodesXi
HS Code2925190090

Customs

HS Code2925190090
Summary2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

[2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
N-(2-((tert-butoxycarbonyl)amino)ethyl)-maleimide
N-(tert.-butyloxycarbonyl)-2-(N-maleinimido)ethylamine
N-Boc-2-Maleimidoethylamine
tert-Butyl (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)carbamate
N-BOC-2-malemidoethylamine
1-((N-tert-butoxycarbonyl)-2-aminoethyl)maleimide
N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester
2-(maleimido)ethylcarbamic acid tert-butyl ester
N-(2-[(Boc)amino]ethyl)maleimide
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