Introduction：Basic information about CAS 133550-41-1|AG 556, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AG 556 |
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| CAS Number | 133550-41-1 | Molecular Weight | 336.38400 |
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| Density | 1.247g/cm3 | Boiling Point | 636.1ºC at 760mmHg |
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| Molecular Formula | C20H20N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 338.5ºC |
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Names
| Name | (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide |
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| Synonym | More Synonyms |
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AG 556 BiologicalActivity
| Description | (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2]. |
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| Related Catalog | Signaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRResearch Areas >>Inflammation/Immunology |
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| References | [1]. Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34(6):1896-907. [2]. George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74(3):314-8. |
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Chemical & Physical Properties
| Density | 1.247g/cm3 |
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| Boiling Point | 636.1ºC at 760mmHg |
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| Molecular Formula | C20H20N2O3 |
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| Molecular Weight | 336.38400 |
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| Flash Point | 338.5ºC |
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| Exact Mass | 336.14700 |
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| PSA | 93.35000 |
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| LogP | 3.53478 |
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| Vapour Pressure | 8.95E-17mmHg at 25°C |
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| Index of Refraction | 1.638 |
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| Storage condition | -20°C |
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Safety Information
Synonyms
| Tyrphostin B 56 |
| AG 556 |
| TYRPHOSTIN AG 556 |
