CAS 167114-91-2|Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt
| Common Name | Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 167114-91-2 | Molecular Weight | 1822.12000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C64H116N22O19 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Autocamtide 2-related inhibitory peptide |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>CaMKSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological Disease |
| Target | IC50: 40 nM (CaMKII)[1]. |
| In Vitro | It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1]. |
| References | [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12. |
Chemical & Physical Properties
| Molecular Formula | C64H116N22O19 |
|---|---|
| Molecular Weight | 1822.12000 |
| Exact Mass | 1821.07000 |
| PSA | 746.43000 |
| LogP | 8.46970 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22-36 |
| Safety Phrases | 22-24/25-26 |
| RIDADR | NONH for all modes of transport |
Articles20
More Articles| CaMKII Controls Whether Touch Is Painful. J. Neurosci. 35 , 14086-102, (2015) The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is evident in the process... | |
| Silanization-Based Zeolite Crystallization: Participation Degree and Pathway. Chemistry 21 , 12161-70, (2015) A clear and deep understanding of zeolite crystallization with the addition of organosilane is desirable for the reasonable design and preparation of hierarchical zeolites. Herein, the effects of diff... | |
| Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII. Cardiovasc. Res. 107 , 184-96, (2015) Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late ... |
Synonyms
| AIP [Ala9]-Autocamtide 2 |
| Autocamtide-2-related inhibitory peptide |
