CAS 74209-34-0|3-Bromo-7-nitro-1H-indazole
| Common Name | 3-Bromo-7-nitro-1H-indazole | ||
|---|---|---|---|
| CAS Number | 74209-34-0 | Molecular Weight | 242.030 |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 437.3±25.0 °C at 760 mmHg |
| Molecular Formula | C7H4BrN3O2 | Melting Point | 175-185 °C |
| MSDS | USA | Flash Point | 218.3±23.2 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | 3-Bromo-7-nitro-1H-indazole |
|---|---|
| Synonym | More Synonyms |
3-Bromo-7-nitro-1H-indazole BiologicalActivity
| Description | 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Neurological Disease |
| Target | nNOS[1] |
| References | [1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25. |
Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.3±25.0 °C at 760 mmHg |
| Melting Point | 175-185 °C |
| Molecular Formula | C7H4BrN3O2 |
| Molecular Weight | 242.030 |
| Flash Point | 218.3±23.2 °C |
| Exact Mass | 240.948685 |
| PSA | 74.50000 |
| LogP | 2.52 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.764 |
| InChIKey | NFSTZPMYAZRZPC-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])c1cccc2c(Br)[nH]nc12 |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 25 mg/mL |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 60 |
| Safety Phrases | S53-S22-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles6
More Articles| Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function. Neuropharmacology 86 , 273-81, (2014) Ketamine is a non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonist of interest in neuropsychiatry. In the present studies, we examined the effects of subanesthetic, low micromolar ketamine... | |
| Role of nitric oxide in traumatic brain injury in the rat. J. Neurosurg. 89 , 807-818, (1998) Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains... | |
| 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57 , PL131-PL135, (1995) The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung... |
Synonyms
| 3-bromo-7-nitro-2H-indazole |
| 3-Bromo-7-nitro-1H-indazole |
| MFCD00159910 |
| 1H-Indazole, 3-bromo-7-nitro- |
