CAS 34450-18-5|17-ODYA
| Common Name | 17-ODYA | ||
|---|---|---|---|
| CAS Number | 34450-18-5 | Molecular Weight | 280.445 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 400.8±18.0 °C at 760 mmHg |
| Molecular Formula | C18H32O2 | Melting Point | 142-148 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 194.7±15.9 °C |
Names
| Name | 17-Octadecynoic acid |
|---|---|
| Synonym | More Synonyms |
17-ODYA BiologicalActivity
| Description | Alkynyl Stearic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 400.8±18.0 °C at 760 mmHg |
| Melting Point | 142-148 °C(lit.) |
| Molecular Formula | C18H32O2 |
| Molecular Weight | 280.445 |
| Flash Point | 194.7±15.9 °C |
| Exact Mass | 280.240234 |
| PSA | 37.30000 |
| LogP | 6.86 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.470 |
| InChIKey | DZIILFGADWDKMF-UHFFFAOYSA-N |
| SMILES | C#CCCCCCCCCCCCCCCCC(=O)O |
| Storage condition | Store at RT |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2916190090 |
Customs
| HS Code | 2916190090 |
|---|---|
| Summary | 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |
Articles33
More Articles| Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection. Proteomics 15 , 2066-77, (2015) Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane i... | |
| Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility. Int. J. Obes. 39 , 755-61, (2015) Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-... | |
| Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans. Drug Metab. Pharmacokinet. 26(3) , 300-6, (2011) The oral bioavailability of some drugs is markedly lower in cynomolgus monkeys than in humans. One of the reasons for the low bioavailability in cynomolgus monkeys may be the higher metabolic activity... |
Synonyms
| Octadec-17-ynoic acid |
| 17-Octadecynoic acid |
| MFCD00077382 |
