Introduction：Basic information about CAS 162870-29-3|(S)-3,5-DHPG, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-3,5-DHPG |
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| CAS Number | 162870-29-3 | Molecular Weight | 183.161 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 448.8±33.0 °C at 760 mmHg |
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| Molecular Formula | C8H9NO4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 225.2±25.4 °C |
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Names
| Name | (S)-3,5-Dihydroxyphenylglycine hydrate |
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| Synonym | More Synonyms |
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(S)-3,5-DHPG BiologicalActivity
| Description | (S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| Target | mGluR1a:0.9 μM (Ki) mGluR5a:3.9 μM (Ki) |
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| In Vitro | (S)-3,5-DHPG specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites[1]. |
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| In Vivo | (S)-3,5-DHPG (icv; 0.01, 0.1 and 1.0 nmol/5 μL) improves consolidation and retrieval and exhibits anxiolytic activity in dose-dependent manner in male Wistar rats weighing 160-180 g subjected to hypoxia[2]. |
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| References | [1]. V Mutel, et al. Characterization of [(3)H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75(6):2590-601. [2]. Agnieszka Nadlewska, et al. Effect of (S)-3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54(1):11-8. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 448.8±33.0 °C at 760 mmHg |
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| Molecular Formula | C8H9NO4 |
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| Molecular Weight | 183.161 |
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| Flash Point | 225.2±25.4 °C |
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| Exact Mass | 183.053162 |
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| PSA | 103.78000 |
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| LogP | -0.52 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.680 |
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| InChIKey | HOOWCUZPEFNHDT-ZETCQYMHSA-N |
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| SMILES | NC(C(=O)O)c1cc(O)cc(O)c1 |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Benzeneacetic acid, α-amino-3,5-dihydroxy-, (αS)- |
| (2S)-Amino(3,5-dihydroxyphenyl)acetic acid |
| Amino(3,5-dihydroxyphenyl)acetic acid |
| Benzeneacetic acid, α-amino-3,5-dihydroxy- |
| (2S)-amino(3,5-dihydroxyphenyl)ethanoic acid |
| UNII:5YR2N37E6D |
| (S)-3,5-DHPG,(S)-3,5-Dihydroxyphenylglycine |
