Introduction：Basic information about CAS 160588-45-4|DMP 543, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DMP 543 |
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| CAS Number | 160588-45-4 | Molecular Weight | 412.43 |
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| Density | 1.319g/cm3 | Boiling Point | 593.1ºC at 760mmHg |
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| Molecular Formula | C26H18F2N2O | Melting Point | / |
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| MSDS | / | Flash Point | 312.5ºC |
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Names
| Name | 10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one |
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| Synonym | More Synonyms |
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DMP 543 BiologicalActivity
| Description | DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | KV7 channel |
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| In Vitro | DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2]. |
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| References | [1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. |
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Chemical & Physical Properties
| Density | 1.319g/cm3 |
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| Boiling Point | 593.1ºC at 760mmHg |
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| Molecular Formula | C26H18F2N2O |
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| Molecular Weight | 412.43 |
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| Flash Point | 312.5ºC |
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| Exact Mass | 412.13900 |
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| PSA | 42.85000 |
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| LogP | 5.07070 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.643 |
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| InChIKey | MUJBUUDUXGDXLW-UHFFFAOYSA-N |
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| SMILES | O=C1c2ccccc2C(Cc2ccnc(F)c2)(Cc2ccnc(F)c2)c2ccccc21 |
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Synonyms
| HMS3268N10 |
| TCN 237 dihydrochloride |
| DMP 543 |
