Introduction：Basic information about CAS 139051-78-8|L-689,560, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-689,560 |
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| CAS Number | 139051-78-8 | Molecular Weight | 380.22500 |
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| Density | 1.51g/cm3 | Boiling Point | 549.1ºC at 760 mmHg |
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| Molecular Formula | C17H15Cl2N3O3 | Melting Point | 172-173ºC |
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| MSDS | / | Flash Point | 285.9ºC |
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Names
| Name | L-689,560,trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline |
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| Synonym | More Synonyms |
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L-689,560 BiologicalActivity
| Description | L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vitro | L-689560 is a 2-carboxytetrahydroquinoline antagonist[2]. |
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| In Vivo | L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1] Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1] Dosage: 1 mg/kg Administration: IP Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors. |
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| References | [1]. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017 [2]. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35. |
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Chemical & Physical Properties
| Density | 1.51g/cm3 |
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| Boiling Point | 549.1ºC at 760 mmHg |
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| Melting Point | 172-173ºC |
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| Molecular Formula | C17H15Cl2N3O3 |
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| Molecular Weight | 380.22500 |
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| Flash Point | 285.9ºC |
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| Exact Mass | 379.04900 |
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| PSA | 90.46000 |
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| LogP | 4.72690 |
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| Vapour Pressure | 6.81E-13mmHg at 25°C |
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| Index of Refraction | 1.683 |
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| InChIKey | UCKHICKHGAOGAP-UHFFFAOYSA-N |
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| SMILES | O=C(Nc1ccccc1)NC1CC(C(=O)O)Nc2cc(Cl)cc(Cl)c21 |
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| L-689,560 |
| 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline |
| TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE |
